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+ A body-ready, fourth generation patented folate - Quatrefolic®
+ Proprietary soluble fiber increases stability
+ Vegetarian, micro capsule size, easy to swallow

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Folate is known as vitamin B9; as humans (and other mammals) cannot synthesize folates, they must be obtained via diet. Folate is found in dark green leafy vegetables (spinach and brussels sprouts), beans, nuts, and even peas in addition to the animal products such as milk and dairy products, egg yolk, and liver. However, natural food-derived folate is unstable and easily oxidized, and it is quickly lost during cooking, processing or storage. Fresh leafy vegetables stored at room temperature may lose up to 70% of their folate activity within three days and a cooking process in water can increase the loss to 95%.

Food folates (the first generation) are susceptible to oxidation, they rapidly lose activity in foods and have a bioavailability range of 25-50%, depending on kind of food.

On the contrary, folic acid, the synthetic form of Monoglutamyl Folate, is almost completely stable for months or even years and can be considered as a “second generation folate". It is also a common type of folic acid supplement on the market. The disadvantage of folic acid is it generally has lower body availability. In fact, whether it is a general food source or synthetic folic acid, after human's consumption, it needs to be converted to 5-MTHF type before the human body can use it. The conversion ability however may be affected by many factors.

The calcium salt of 5-methyltetrahydrofolate is available commercially and represents the third generation of folate. Until now, 5-methyltetrahydrofolate calcium salt was the only folic acid derivative available on the market, and able to penetrate the body cells without the need of further metabolism process. Its absorption rate towards the human body has been significantly improved. However, this type of folate has not been approved by the Ministry of Health and Welfare of Taiwan, it still needs to pass the safety verification. In short, calcium salt type folic acid is an unapproved ingredient to be used in nutritional products under Taiwan's law.

As for (6S)-5-Methyltetrahydrofolate Glucosamine Salt (Quatrefolic®), it represents the fourth generation folate endowed with long lasting stability as well as a peculiarly high water solubility, improved bioavailability and well established safety. Studies have shown that Quatrefolic®'s water solubility is 100 times more soluble than the third generation calcium salt type of folate. Its absorption rate in the human body, and the safety has also been confirmed by many clinical trials. After a long period of evaluation and review, the US FDA has officially approved Quatrefolic® as a safe and edible nutritional ingredient [New Dietary Ingredient (NDI)].

ACTIVFOLATE by realpromise used "BODY-READY" Methyltetrahydrofolate (6S)-5-MTHF - Quatrefolic®, which is a naturally reduced form with much better stability, higher solubility, and greater bioavailability. ACTIVFOLATE has been confirmed by researches that it has better activity and can be directly converted; it is also better absorbed than traditional folic acid and can be stored in the body. 



ACTIVFOLATE also added citric acid and chose patented Fibryxa® from Japan - a water-soluble dietary fiber, to increase the stability of folate. The micro capsules were France-imported, it is not only vegetarian friendly, but also more suitable for the need of Asian pregnant women. Our goal is to make the product easier to swallow, thus reducing the discomfort and rejection from the users.

Folate is a crucial nutrient for all of us: women, pregnant or not, and men as well. Folate is like a master switch in a physical process called the methylation cycle. This is the mechanism that allows our bodies to function by turning on and off the individual biological switches for a host of body systems. When folate is working optimally, it has a significant positive impact on the formation of red blood cells, the formation of nucleic acids and nucleoproteins, and helps the normal development and growth of fetus.

Folate is a water-soluble vitamin and cannot be stored in the body for a long time. Since the body cannot produce folate on its own and it is difficult to store it in the body, it's recommended to supplement folate daily via diet or dietary supplements. According to the analysis of the nutritional status of folate in Taiwan for the past ten years, the amount of intake of dark green vegetables and fruits for adults 19-30 years old is low, which will indeed affect the intake of folate. Meanwhile, 19-30 years old is also the peak group for pregnancy and preparing for pregnancy. Insufficient folate intake will have a corresponding negative effect.

ACTIVFOLATE is a formula specially designed for pregnant women. It’s common knowledge that folate is one of the most important B vitamins to take during pregnancy. Every ACTIVFOLATE capsule contains 400 mcg of patented (6S)-5- Methyltetrahydrofolate Glucosamine Salt, which is more active, can be used directly, can be better absorbed than synthetic folic acid as well. ACTIVFOLATE meets the suggested daily dose for pregnant woman from American Pregnancy Association (APA) - it suggests to consume 400 – 800 mcg of folate everyday throughout entire pregnancy. If you’re trying to conceive, it’s also recommended that you consume this same amount of folate (400 mcg for pre-pregnancy is generally fine) to maximize your chances of getting pregnant. In late pregnancy, please adjust the content of folate according to the recommendations of the doctor or medical professional. Choose well-absorbed ACTIVFOLATE for your unborn baby's health! ‎‎


At realpromise, purity verification is the highest priority in every aspect. From the purity and safety of raw materials to quality control; to the finished product inspection, we choose to work with international third-party independent laboratory and certifiers to verify that each batch of our products meets our quality control requirements and production standards to ensure our quality can bring the greatest benefit to the customers. We inspect more than hundreds of items regarding safety, in order to ensure that you can have the highest purity products. Each batch of our products has passed at least 600 rigorous inspections and analyses, including four major heavy metal inspections, harmful microorganism inspections, 410 pesticide residue inspections and 233 qualitative screening test of chemicals for clinical use. In addition, some products will undergo activity monitoring, or do more purity testing for special ingredients. For example, Babe D3 has added 12 preservatives testing and 9 multi-mycotoxins testing. Our quality is worthy of your trust; please feel at ease to take the high-purity dietary supplements carefully designed by realpromise.


Our manufacturing factories have passed many certifications. Whether it is a manufacturing factory in Canada or Taiwan, we only choose the most stringent standard applicable for any process line to produce our carefully developed products. Our C.A. manufacturing factory has GMP and U.S. FDA (Food and Drug Administration) certification, as well as HALAL certification. The manufacturing factory in Taiwan is certified by a third-party organization - U.K. URS, which complies with HACCP and ISO 22000 safety regulations. The highest quality is worthy of your trust and confidence.


At realpromise, we make a conscious effort to avoid preservatives and harmful artificial chemical additives. When researching formulations and manufacturing, purity and safety are always our uncompromising principle. We insist on never using the following ingredients in our products, we will definitely keep a close eye out for you.


We are convinced that quality and efficacy are the cornerstones of nutritional supplements, which is also our guarantee to you. The use of inferior raw materials for the sake of cost will deeply affect the quality and effectiveness after consumption, so we only use the clinically-proven raw materials from well-known brands. In our opinion, the so-called high-quality dietary supplements must meet the following three standards :

Absorption Rate:For high-quality nutritional supplements, the efficacy after consumption depends on the absorption rate of the ingredients themselves. After all, the efficacy is highly related to the form of the ingredients. We insist on using the raw materials with highest-quality active form available to ensure our customers can achieve the best results after taking in our products.

Origin:The origin of the ingredients is the crucial point. Our principle in terms of choosing ingredients includes 1). The efficacy has been validated by a number of clinically trials. 2). The raw materials have to be from high-purity well-known brands. 3). The proof of high absorption rate and active form. Moreover, we never use inferior artificial chemicals to synthesize nutrients.

Form:Our products are mainly in the form of transparent capsules. Capsule formats are safer than tablets, because many additives have to add to tablets during molding process. Meanwhile, artificial colors and titanium dioxide are added to make colored capsules/tablets. All of these could cause potential harms to your body. Rejecting to use any risky substances in our products is our promise. In addition, realpromise is also extremely careful in the choice of capsule sizes. We understand the sizes of the capsules could affect the user acceptance and compliance. We intend to make the product easier to swallow, thus reducing the discomfort and rejection from the users. We always try to stand on the perspective of our consumers, and provide the best nutritional supplements without putting your feelings on the back burner.

When should I start taking ActivFolate? How much should I take?

Under normal circumstance, it is recommended to start ACTIVFOLATE 3 months before you start trying to conceive. In short, the most critical period for ACTIVFOLATE supplementation is 6 months - 3 months before conception and the first 3 months of pregnancy. This is not saying there in no need to supplement ACTIVFOLATE at other times. In fact, an appropriate amount of folate is needed throughout pregnancy. All women of childbearing age should at least take about one capsule of ACTIVFOLATE (400 mcg) each day, which can support the healthy development of the fetus.

Which kind of folate should I choose?

Due to some genetic influences from Asian, the general folic acid cannot be metabolized, and there may be side effects after taking. ACTIVFOLATE is the latest fourth-generation folate, which can be directly used in human body after taking to avoid the problems caused by gene.

If I get pregnant unplanned, should I increase the dose of folic acid supplement?

Since the development of the fetus often occurs within the first 2-4 weeks of pregnancy, it is very important to get enough folate in the first trimester. If you find an unplanned pregnancy, you should start folate supplement immediately, Whether you should increase the amount of intake, please consult a gynaecologist or a medical professional.

After taking "ActivFolate" supplement for 3 months, I am still not conceived. Should I continue to take it?

It is very safe to supplement 400 mcg of folate daily, even if you take it for a long period of time. Therefore, if you do not plan to give up having a baby, you can continue to take ACTIVFOLATE supplement.

Should I take ActivFolate before or after meals?

Both are fine. In general, you can take ActivFolate with or without food, as long as you take ActivFolate at the same time every day, whether it is morning or evening. However, some experts suggest that folate should be taken half an hour or an hour after a meal. For 24 hours a day, taking ActivFolate in the morning is the best, especially after half an hour or one hour after breakfast; the absorption rate is considered higher.

Can I get enough folic acid from my diet alone?

Many people think getting nutrients from food is safer than from supplements. If you can get enough nutrition from food, try not to take supplements at all. Although green leafy vegetables, fruits, and animal livers contain a lot of folate, the folate losses during harvesting, processing, and cooking is as high as 50% to 90%. Heating especially causes the biggest damage to folate. Thus, it’s difficult to get the amount of folate recommended for pregnant women from food alone. Therefore, taking ActivFolate supplement is necessary, as long as you follow the intake instructions from medical professionals, you have no need to worry about side effect.

Folic acid is contained in a lot of nutritional supplements and powdered milk drink for pregnant women, will I have folate overdose problems?

In addition to folate supplements mentioned above, some vitamins and powdered milk drink for pregnant women also contain folic acid. Mothers-to-be should choose according to their own need and circumstances. No matter which one is chosen, the intake amount of folate daily should be counted. The total amount has to at least reach 400 mcg and no more than 1000 mcg; or consult a physician or medical professionals before use.

Other Ingredients : Isomaltodextrin, Citric Acid, Hydroxycellulose Methylcellulose, Water.
Size : 30 Count.
Suggested Use : One capsule daily, or as directed by your healthcare professional.
Caution : 1). Keep tightly closed in a cool, dry place away from sunlight.  2). Keep out of reach of children.  3). If taking other nutritional supplements or medication, consult your healthcare practitioner before use.
Product Effective Date : 24 Months.
Storage : Keep tightly closed in a cool, dry place away from sunlight.
Manufacturer : Real Promise Co. Ltd.
Food Enterprises Registration No : A-152427266-00000-2.
Origin : Taiwan.
Product Liability Insurance : This product has been insured by Tokio Marine News Insurance Co., Ltd. Insurance no : 1702010ML000404.
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