Natural folates (the first generation) are susceptible to oxidation, they rapidly lose activity in foods and have a bioavailability range of 25-50%, depending on kind of food.
On the contrary, folic acid, the synthetic form of Monoglutamyl Folate, is almost completely stable for months or even years and can be considered as a “second generation of folate, the stable one”. 5-Methyltetrahydrofolate Calcium Salt is the third generation, it was the only folic acid derivative available on the market, and able to penetrate the body cells without further metabolism.
ACTIVFOLATE uses Quatrefolic, the fourth generation folate derivatives, a new generation of folate derivative made up of (6S)-5-Methyltetrahydrofolate Glucosamine Salt which is able to overcome the existing calcium salt form limitations related to stability, poor solubility and bioavailability.
ACTIVFOLATE demonstrates a surprisingly high solubility in water – greater than 1 g/ml – compared with the slight solubility of the reference compound, (6S)-5-Methyltetrahydrofolate Calcium Salt (1.1 g/100 ml). ACTIVFOLATE is about 100 times more soluble than the calcium salt. The patented folate used in ACTIVFOLATE has been shown in preclinical and clinical studies to have a higher bioavailability than calcium salt derivatives. ACTIVFOLATE also chooses patented soluble fiber from Japan to increase stability of folate. Small size capsule makes it easier for Asian and pregnant women to swallow.
Every ACTIVFOLATE capsule contains 400 mcg of patent (6S)-5- Methyltetrahydrofolate Glucosamine Salt. It meets the suggested daily dose for pregnant woman from American Pregnancy Association (APA). It’s common knowledge that folic acid is one of the most important B vitamins to take during pregnancy. APA suggests consuming 400 – 800 mcg of folate everyday throughout entire pregnancy. If you’re trying to conceive, it’s also recommended that you consume this same amount of folic acid (400 mcg for pre-pregnancy is generally fine) to maximize your chances of getting pregnant.
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Q : ACTIVFOLATE: When should I start taking It? How much should I take ?
A : Under normal circumstance, it is recommended to start ACTIVFOLATE 3 months before you start trying to conceive. In short, the most critical period for ACTIVFOLATE supplementation is 6 months - 3 months before conception and the first 3 months of pregnancy. This is not saying there in no need to supplement ACTIVFOLATE at other times. In fact, an appropriate amount of folate is needed throughout pregnancy. All women of childbearing age should at least take about one capsule of ACTIVFOLATE (400 mcg) each day, which can support the healthy development of the fetus.
Q : Which kind of folate should I choose ?
A : Due to some genetic influences from Asian, the general folic acid cannot be metabolized, and there may be side effects after taking. ACTIVFOLATE is the latest fourth-generation folate, which can be directly used in human body after taking to avoid the problems caused by gene.
Q : If I get pregnant unplanned, should I increase the dose of folate supplement ?
A : Since the development of the fetus often occurs within the first 2-4 weeks of pregnancy, it is very important to get enough folate in the first trimester. If you find an unplanned pregnancy, you should start folate supplement immediately, Whether you should increase the amount of intake, please consult a gynaecologist or a medical professional.
Q : After taking ACTIVFOLATE for 3 months, I am still not conceived. Should I continue to take it ?
A : It is very safe to supplement 400 mcg of folate daily, even if you take it for a long period of time. Therefore, if you do not plan to give up having a baby, you can continue to take ACTIVFOLATE supplement.
Q : Take ACTIVFOLATE before or after meals ?
A : Both are fine. In general, you can take ACTIVFOLATE with or without food, as long as you take ACTIVFOLATE at the same time every day, whether it is morning or evening. However, some experts suggest that folate should be taken half an hour or an hour after a meal. For 24 hours a day, taking ACTIVFOLATE in the morning is the best, especially after half an hour or one hour after breakfast; the absorption rate is considered higher.
Q : Can I get enough folate from my diet alone ?
A : Many people think getting nutrients from food is safer than from supplements. If you can get enough nutrition from food, try not to take supplements at all. Although green leafy vegetables, fruits, and animal livers contain a lot of folate, the folate losses during harvesting, processing, and cooking is as high as 50% to 90%. Heating especially causes the biggest damage to folate. Thus, it’s difficult to get the amount of folate recommended for pregnant women from food alone. Therefore, taking ACTIVFOLATE supplement is necessary, as long as you follow the intake instructions from medical professionals, you have no need to worry about side effects.
Q : Folic acid are contained in a lot of nutritional supplements and powdered milk drink for pregnant women, will I have folate overdose problems ?
A : In addition to folate supplements mentioned above, some vitamins and powdered milk drink for pregnant women also contain folic acid. Mothers-to-be should choose according to their own need and circumstances. No matter which one is chosen, the intake amount of folate daily should be counted. The total amount has to at least reach 400 mcg and no more than 1000 mcg; or consult a physician or medical professionals before use.